Bengt Saltin. “Don’t be sad it is over – be glad that it happened”

“Not Everything That Is Faced Can Be Changed, but Nothing Can Be Changed Until It Is Faced”: A Response to Recent Commentaries

Is it jolly SAD?

Examples of phasing macromolecular crystal structures based on single-wavelength anomalous dispersion (SAD) have demonstrated that this approach may have general applications in structural biology. With better data-collection facilities and cryogenic techniques, combined with powerful data-processing, phasing and density-modification programs, the SAD approach may prove simpler than phasing fro...

If it is to be, it is up to me.

Tigecycline: what is it, and where should it be used?

Tigecycline is the first glycylcycline to be launched and is one of the very few new antimicrobials with activity against Gram-negative bacteria. It evades acquired efflux and target-mediated resistance to classical tetracyclines, but not chromosomal efflux in Proteeae and Pseudomonas. Cmax+ is low, but tissue penetration is excellent and the compound has shown equivalence to imipenem/cilastati...

Artificial Intelligence: What It Is, and What It Should Be

What Artificial Intelligence (AI) is at the current time is not what it should be. The mainstream works in the field are on domain-specific problems and solutions. Instead, AI should focus on general-purpose systems that are adaptive to its environment, and can work with insufficient knowledge and resources. AI in this sense is unified with Cognitive Science at a general level, with the latter ...